What Treatments are Likely to Cause Mouth Sores?

While there are many chemotherapy drugs that cause oral mucositis (painful, debilitating mouth sores) it is more common with certain treatments.

These drugs have been reported to cause mucositis:

  • Actinomycin (Cosmegen)
  • Busfulan (Myleran®, Busulfex®)
  • Cytarabine (Cytosar-U®)
  • Daunorubicin (Cerubidine®)
  • Docetaxel (Taxotere®)
  • Doxorubicin (Adriamycin®, Rubex®)
  • Epirubcin (Ellence®)
  • Floxuride (FUDR®)
  • Fluorouracil (5-FU, Adrucil®, Carac®, Efudex®, Fluoroplex®)
  • Idarubicin (Idamycin®, Idamysin PFS®)
  • Isotretinoin (Accutane®)
  • Liposomal doxorubicin (Dox)
  • Methotrexate (Rheurnatrex®)
  • Mitomycin (Mutamycin®)
  • Mitoxantrone (Novantrone®)
  • Mechlorethamine (Mustargen®)
  • Oprevelkin (Neumega®)
  • Paclitaxel (Taxol®, Onxal®)
  • Pemetrexed (Alimta®)
  • Alemtuzumab (Campath®)
  • Asparaginase (Elspar®, Kidrolase®)
  • Bleomycin (Blenoxane®)
  • Capecitabine (Xeloda®)
  • Carboplatin (Paraplatin®)
  • Cyclophosphamide (Cytoxan®, Neosar®)
  • Etoposide (VePesid®, Toposar®, Etopophos®)
  • Gemcitabine (Gemzar®)
  • Gemtuzumab ozogamicin (Mylotarg®)
  • Hydroxyurea (Hydrea®)
  • Interleukin 2 (Proleukin®)
  • Iriotecan (Camptosar®)
  • Liposomal daunorubicin (DaunoXome®)
  • Lomustine (CeeNU®)
  • Melphalan (Alkeran®)
  • Oxaliplatin (Eloxatin®)
  • Pentostatin (Nipent®)
  • Rasburicase (Elitek®)
  • Thiotepa (Thioplex®)
  • Topotecan (Hycamtin®)
  • Trastuzumab (Herceptin®)
  • Tretinoin (Vesanoid®)
  • Vinblastine (Velban®, Alkaban AQ®)
  • Vincristine (Oncovin®, Vincasar PFS®)

Careful oral hygiene can help prevent mouth sores, gum disease, and tooth decay.

Click here to find out what special steps are needed while undergoing treatment.